Su1013 – Increased Basophil Recruitment to the Colon of Ulcerative Colitis Patients and Oxazolone-Induced Mice Colitis Possibly Through Ccl2-Ccr2 Axis
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چکیده
منابع مشابه
Oxazolone-induced colitis in BALB/C mice: a new method to evaluate the efficacy of therapeutic agents for ulcerative colitis.
A number of experimental models of colitis have been proposed. However, few studies have presented T helper-2 (Th-2) type colitis models that substitute for human ulcerative colitis (UC). In recent years, the murine oxazolone (OXA)-induced colitis model came to be accepted as a Th-2 type model, but it has yet to be used in any pharmacological study. In the present study, we modified the OXA-ind...
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Objective(s): Ulcerative colitis (UC) is a kind of complex immune disease, and a major cause of destruction of intestinal barrier and oxidative stress in this field. In this paper, glutamine (Gln) was believed to offer protection against oxidative stress injury in colitis mice.Materials and Methods: Thirty mice were randomly assigned int...
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The inflammasomes induce maturation of pro-interleukin-1β (IL-1β) and pro-IL-18. We investigated roles of the NLRP3 inflammasome in the pathogenesis of ulcerative colitis (UC). After induction of oxazolone-induced colitis, a mouse UC model, colonic tissues were assayed for inflammatory mediators. Histological studies were performed on inflamed colonic tissue from mice and UC patients. Histologi...
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To cite: Gruenhagen B, Alraies MC, Vakil KP, et al. BMJ Case Rep Published online: [please include Day Month Year] doi:10.1136/ bcr-2014-204818 DESCRIPTION A 24-year-old man presented with a 2 h history of substernal chest pain radiating to both arms with associated dyspnoea, diaphoresis and dizziness. He also reported a 3-week history of abdominal cramping with multiple loose bloody bowel move...
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ژورنال
عنوان ژورنال: Gastroenterology
سال: 2019
ISSN: 0016-5085
DOI: 10.1016/s0016-5085(19)38072-2